Neurocardiac Crosstalk: Sympathetic Remodeling and Arrhythmogenesis After Myocardial Infarction
Tianshui Yu, Dumitru A Iacobas · 2025
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Description
Tianshui Yu and a colleague present a 2025 review on how nerve remodeling after a heart attack sets the stage for dangerous heart rhythms. The heart's sympathetic nerves form a control network running from the brain's outer layers down to small ganglia near the heart. After a heart attack, this whole axis changes shape. The review gathers the anatomy and the mechanisms level by level.
In the brain, inflammation rises along the network's centers. Near the heart, nerve fibers sprout unevenly and grow too dense in patches. The authors trace key signaling pathways behind these changes, including inflammatory switches in the brain and ganglia. Uneven nerve growth can throw the heart's rhythm into chaos and sudden death. The review aims to give clinicians and researchers a shared map of this nerve-heart crosstalk.
Catalog record
| CREATOR | Tianshui Yu, Dumitru A Iacobas |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 54 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |