Short-Term Dietary Exposure to Ochratoxin A, Zearalenone or Fumonisins in Broiler Chickens: Effects on Cytochrome P450 Enzymes, Drug Transporters and Antioxidant Defence Systems
Neenu Amminikutty, Matteo Cuccato, Watanya Jarriyawattanachaikul, Marta Gariglio, Donato Greco, Vito D’Ascanio, Giuseppina Avantaggiato, Achille Schiavone, Carlo Nebbia, Flavia Girolami · 2025
Read Short-Term Dietary Exposure to Ochratoxin A, Zearalenone or Fumonisins in Broiler Chickens: Effects on Cytochrome P450 Enzymes, Drug Transporters and Antioxidant Defence Systems by Neenu Amminikutty, Matteo Cuccato, Watanya Jarriyawattanachaikul, Marta Gariglio, Donato Greco, Vito D’Ascanio, Giuseppina Avantaggiato, Achille Schiavone, Carlo Nebbia, Flavia Girolami (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12732176.txt.
Description
Feed fungi leave poisons called mycotoxins in grain, and chickens eating them face more than gut trouble. Amminikutty and co-authors fed broiler chickens one of three common mycotoxins for ten days, at levels above European guidance but seen in some countries. They then measured the birds' antioxidant defenses and the liver and gut genes that handle drugs and toxins.
All three poisons drained a key antioxidant in the liver and raised fat damage there, and one cut the blood's total antioxidant capacity. The toxins also dialed down protective enzymes by way of the Nrf2 control pathway. At the same time they reshuffled the genes for drug-processing enzymes and generally turned up the transporter genes that pump substances out of cells. The authors warn that such shifts can change how medicines and other toxins behave in the bird, a food safety concern.
Catalog record
| CREATOR | Neenu Amminikutty, Matteo Cuccato, Watanya Jarriyawattanachaikul, Marta Gariglio, Donato Greco, Vito D’Ascanio, Giuseppina Avantaggiato, Achille Schiavone, Carlo Nebbia, Flavia Girolami |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 42 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |