Oncolytic Virotherapy in Colorectal Cancer: Mechanistic Insights, Enhancer Strategies, and Translational Combinations
Huda Salameh, Nesha Naseem, Muhammad A. Chattha, Joytish Ramesh, Haneen Ramy, Dasa Cizkova, Peter Kubatka, Dietrich Büsselberg · 2025
Read Oncolytic Virotherapy in Colorectal Cancer: Mechanistic Insights, Enhancer Strategies, and Translational Combinations by Huda Salameh, Nesha Naseem, Muhammad A. Chattha, Joytish Ramesh, Haneen Ramy, Dasa Cizkova, Peter Kubatka, Dietrich Büsselberg (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12732131.txt.
Description
Viruses engineered to grow only in cancer cells offer a new angle on colorectal cancer, which still lacks good options for most patients. Huda Salameh and co-authors review 101 primary studies of such oncolytic viruses in this 2025 paper. The studies sort into virus-only therapy, combinations with other treatments, and enhancer tricks that sharpen targeting.
Alone, the viruses reliably burst tumor cells and sometimes stirred immunity and cut blood supply to tumors. Pairing them with immune checkpoint drugs worked better still, drawing T cells in and controlling even resistant tumors. Delivery by stem cells and tumor-specific switches improved aim and reach. The authors call for proper clinical trials, noting models vary widely and human proof lags.
Catalog record
| CREATOR | Huda Salameh, Nesha Naseem, Muhammad A. Chattha, Joytish Ramesh, Haneen Ramy, Dasa Cizkova, Peter Kubatka, Dietrich Büsselberg |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 53 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |