Epigenome-Wide Search for Distinctive Methylation Biomarkers of Endothelial and Leukocyte DNA
Valeria A. Korolenya, Maxim L. Filipenko, Mariya A. Smetanina · 2025
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Description
Valeria Korolenya, Maxim Filipenko, and Mariya Smetanina hunt for markers that tell two kinds of cell DNA apart in a 2025 study. Blood vessel samples mix DNA from the vessel lining and from white blood cells that stick to it. Chemical tags on DNA, called methylation, differ between cell types and could separate the sources.
Using data from gene chips, the team screened for spots where the tag level stays near full or near zero for one cell kind. They found forty-seven spots that separate lining cells from white blood cells in a stable way. They also compared tag patterns among subtypes of each group. The markers should help future studies of vessel lining damage, where telling the DNA sources apart matters.
Catalog record
| CREATOR | Valeria A. Korolenya, Maxim L. Filipenko, Mariya A. Smetanina |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 20 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |