PGE1 Suppresses the Expression of M2 Markers on Macrophages Through Prostaglandin Receptors
Hiroyuki Tsuchiya, Takehiko Hanaki, Jun Yoshida, Mayu Obora, Yoshiyuki Fujiwara, Daisuke Nanba, Hiroshi Miyamoto · 2025
Read PGE1 Suppresses the Expression of M2 Markers on Macrophages Through Prostaglandin Receptors by Hiroyuki Tsuchiya, Takehiko Hanaki, Jun Yoshida, Mayu Obora, Yoshiyuki Fujiwara, Daisuke Nanba, Hiroshi Miyamoto (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12731825.txt.
Description
Hiroyuki Tsuchiya and co-authors show that a prostaglandin drug strips tumor friendly traits from macrophages, in a 2025 paper. The head byline is shorter than the catalog list, so team framing is used. Macrophages of the healing kind help tumors hide from immunity, and flipping them is a therapy goal. The drug had earlier raised attack kind markers.
Cells grown with liver cancer cells in shared balls took on more healing markers than cells grown alone. The drug cut those markers better than close cousins did. Blocking two of its receptors undid the effect, naming the route. The authors pitch the drug and its kin as immune therapy candidates for stubborn cancers.
Catalog record
| CREATOR | Hiroyuki Tsuchiya, Takehiko Hanaki, Jun Yoshida, Mayu Obora, Yoshiyuki Fujiwara, Daisuke Nanba, Hiroshi Miyamoto |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 32 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |