A Specific Haplotype of the MMP2 Gene Promoter May Increase the Risk of Developing Cerebral Palsy
Ana Djuranovic Uklein, Natasa Cerovac, Dijana Perovic, Nela Maksimovic, Biljana Jekic, Milka Grk, Marija Dusanovic Pjevic, Milica Rasic, Natasa Stojanovski, Milica Pesic, Ivana Novakovic, Tatjana Damnjanovic · 2025
Read A Specific Haplotype of the MMP2 Gene Promoter May Increase the Risk of Developing Cerebral Palsy by Ana Djuranovic Uklein, Natasa Cerovac, Dijana Perovic, Nela Maksimovic, Biljana Jekic, Milka Grk, Marija Dusanovic Pjevic, Milica Rasic, Natasa Stojanovski, Milica Pesic, Ivana Novakovic, Tatjana Damnjanovic (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12731818.txt.
Description
Ana Djuranovic Uklein and eleven co-authors test whether gene variants in the MMP2 promoter track cerebral palsy after birth asphyxia, in work from 2025. Oxygen loss at birth can inflame and injure the newborn brain, and matrix enzymes help drive that damage. The study enrolled 212 children with documented perinatal asphyxia, all assessed with brain imaging, and typed three promoter variants.
Children who developed cerebral palsy carried the risk alleles at nearly twice the rate of those who did not. One combined haplotype, ATG, was clearly more common in the palsy group and in children with scan-proven brain damage. The authors propose the haplotype as an early risk marker worth confirming.
Catalog record
| CREATOR | Ana Djuranovic Uklein, Natasa Cerovac, Dijana Perovic, Nela Maksimovic, Biljana Jekic, Milka Grk, Marija Dusanovic Pjevic, Milica Rasic, Natasa Stojanovski, Milica Pesic, Ivana Novakovic, Tatjana Damnjanovic |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 27 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |