Should Fertility Preservation Be Offered to Young Women with Melanoma Receiving Immune Checkpoint Inhibitors? A SWOT Analysis
Diego Raimondo, Michele Miscia, Antonio Raffone, Manuela Maletta, Linda Cipriani, Paola Valeria Marchese, Francesca Comito, Rossella Vicenti, Federica Cortese, Enrico Pazzaglia, Linda Bertoldo, Luigi Cobellis, Renato Seracchioli · 2025
Read Should Fertility Preservation Be Offered to Young Women with Melanoma Receiving Immune Checkpoint Inhibitors? A SWOT Analysis by Diego Raimondo, Michele Miscia, Antonio Raffone, Manuela Maletta, Linda Cipriani, Paola Valeria Marchese, Francesca Comito, Rossella Vicenti, Federica Cortese, Enrico Pazzaglia, Linda Bertoldo, Luigi Cobellis, Renato Seracchioli (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12731626.txt.
Description
Diego Raimondo and twelve co-authors ask whether young women with melanoma should be offered fertility preservation before immune checkpoint treatment. These drugs have reshaped melanoma care and now produce lasting remissions even in high-risk stages. As survival improves, the chance to have children later becomes a real survivorship concern. Yet the reproductive safety of the drugs is still poorly mapped, so the team weighs the case with a structured strengths, weaknesses, opportunities, and threats analysis.
Animal studies of this drug class show immune activation in the ovaries, release of inflammatory signals, and loss of egg follicles. Human data are thinner, resting on marker studies that hint at falling ovarian reserve. Firm numbers await planned studies. Even so, the authors conclude that counseling on preservation should be offered routinely before treatment starts. That step protects a patient's future choices without weakening cancer care.
Catalog record
| CREATOR | Diego Raimondo, Michele Miscia, Antonio Raffone, Manuela Maletta, Linda Cipriani, Paola Valeria Marchese, Francesca Comito, Rossella Vicenti, Federica Cortese, Enrico Pazzaglia, Linda Bertoldo, Luigi Cobellis, Renato Seracchioli |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 39 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |