Western Diet Induces Changes in Gene Expression in Multiple Tissues During Early Insulin Resistance and Glucose Intolerance in Male C57BL/6 Mice
Djordje Radulović, Jurij Dolenšek, Andraž Stožer, Uroš Potočnik, Bogdana Virgolici · 2025
Read Western Diet Induces Changes in Gene Expression in Multiple Tissues During Early Insulin Resistance and Glucose Intolerance in Male C57BL/6 Mice by Djordje Radulović, Jurij Dolenšek, Andraž Stožer, Uroš Potočnik, Bogdana Virgolici (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12731596.txt.
Description
Djordje Radulović and co-authors tracked how a Western diet rewires gene activity across mouse tissues early in diabetes development in a 2025 study. The diet, rich in fat and sugar, drives type 2 diabetes, but the molecular steps in each tissue were not mapped together. Male mice of a standard strain ate control or Western diets.
Tolerance tests confirmed early insulin resistance and glucose intolerance in the Western group. The team then profiled gene expression in the tissues that govern glucose: liver, muscle, fat, and pancreas among them. Seeing which tissue changes first can reveal where intervention bites earliest. The atlas supports the hunt for early markers of diet-driven diabetes.
Catalog record
| CREATOR | Djordje Radulović, Jurij Dolenšek, Andraž Stožer, Uroš Potočnik, Bogdana Virgolici |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 61 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |