Prophylactic Cranial Irradiation in Small Cell Lung Cancer: Evolution of Evidence, Current Status, and Future Directions
Swati Mamidanna, Menal Bhandari, Charvi Shah, Ludvinna Bazile, Sukhdeep Kaur Gill, Adeel Riaz, Lakshmi Rekha Narra, Shreel Parikh, Ahmed Shalaby, Mihir Patel, Zohaib Khan Sherwani, Jongmyung Kim, Matthew P Deek, Salma K Jabbour, Ritesh Kumar, Chan-Yen Kuo · 2025
Read Prophylactic Cranial Irradiation in Small Cell Lung Cancer: Evolution of Evidence, Current Status, and Future Directions by Swati Mamidanna, Menal Bhandari, Charvi Shah, Ludvinna Bazile, Sukhdeep Kaur Gill, Adeel Riaz, Lakshmi Rekha Narra, Shreel Parikh, Ahmed Shalaby, Mihir Patel, Zohaib Khan Sherwani, Jongmyung Kim, Matthew P Deek, Salma K Jabbour, Ritesh Kumar, Chan-Yen Kuo (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12731449.txt.
Description
Swati Mamidanna and fifteen colleagues review the rise, fall, and partial revival of preventive brain radiation in small cell lung cancer. This aggressive cancer seeds the brain often. Irradiating the cranium after successful initial treatment once clearly extended survival, above all in limited-stage disease.
Newer trials with routine MRI surveillance found no survival benefit in extensive-stage disease. That makes watchful scanning, with salvage treatment if needed, a real alternative. Memory damage remains the chief cost, though hippocampus-sparing methods and protective drugs soften it. The arrival of immunotherapy scrambles the calculus further. The review maps where preventive irradiation still earns its place and where scans have taken its place.
Catalog record
| CREATOR | Swati Mamidanna, Menal Bhandari, Charvi Shah, Ludvinna Bazile, Sukhdeep Kaur Gill, Adeel Riaz, Lakshmi Rekha Narra, Shreel Parikh, Ahmed Shalaby, Mihir Patel, Zohaib Khan Sherwani, Jongmyung Kim, Matthew P Deek, Salma K Jabbour, Ritesh Kumar, Chan-Yen Kuo |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 49 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |