The CXCL12/CXCR4 Axis in Sepsis-Induced Acute Lung Injury: Mechanisms and Therapeutic Potential
Renwei Luo, Qinglu Fan, Qingyun Chen, Zhihao Nie, Lingxuan Dan, Songping Xie, Arumugam R Jayakumar · 2025
Read The CXCL12/CXCR4 Axis in Sepsis-Induced Acute Lung Injury: Mechanisms and Therapeutic Potential by Renwei Luo, Qinglu Fan, Qingyun Chen, Zhihao Nie, Lingxuan Dan, Songping Xie, Arumugam R Jayakumar (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12731308.txt.
Description
Renwei Luo and co-authors review a signaling axis that both drives lung injury in sepsis and helps repair it in a 2025 paper. Sepsis can flood and scar the lungs, a deadly complication with few treatments. The chemokine pathway in question guides immune cells and has drawn growing interest for this dual role.
The review joins evidence on how the pathway acts in each major lung cell type, through several downstream routes. It also covers what switches the pathway on, from low oxygen to gene control, and a second receptor that tempers it. Candidate treatments include a known blocking drug, natural products, and gene-tuning agents. The authors weigh the gap between animal findings and human data and sketch precision strategies.
Catalog record
| CREATOR | Renwei Luo, Qinglu Fan, Qingyun Chen, Zhihao Nie, Lingxuan Dan, Songping Xie, Arumugam R Jayakumar |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |