Rethinking the Evolution of Tubulin Polymerization Promoting Proteins
Ferenc Orosz · 2025
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Description
Ferenc Orosz rethinks the family tree of a protein clan tied to cell skeletons. The proteins, called TPPPs, help build microtubules and are sorted by how often a signature piece, the p25alpha domain, appears in them. They turn up across the living world, in animals, fungi, algae, and single-celled life. His 2025 paper argues the accepted map of who has which type is wrong in places.
Searching protein and gene databases, Orosz found fungal-type proteins outside fungi, among other surprises. One type with the signature piece doubled appears only in the animal-and-fungi branch, while another crossed between the two great supergroups of complex life. Protein presence tracked tightly with having a eukaryotic flagellum, the whip-like tail some cells swim with. These exceptions force a redraw of how the family spread and split through deep time.
Catalog record
| CREATOR | Ferenc Orosz |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 34 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |