Mitochondrial Permeability Transition Pore: The Cardiovascular Disease’s Molecular Achilles Heel
Salvatore Nesci, Speranza Rubattu · 2025
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Description
When blood flow returns to heart muscle after a heart attack, a tiny pore inside cell power plants can spring open and kill more cells. Salvatore Nesci and Speranza Rubattu review that pore as a weak point in heart disease in this 2025 paper. Stress, calcium overload, and energy loss all push the pore to open at the worst moment.
Opening wrecks the power plants, triggers cell death, and widens the scar. The review explains how the pore affects each heart cell type in a distinct way and how waste cleanup inside cells goes wrong. It then surveys treatments that target power plant health, including cell transplants. Blocking the pore at the right moment is a long-sought goal, and the paper shows how close the field has come.
Catalog record
| CREATOR | Salvatore Nesci, Speranza Rubattu |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 28 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |