A Fluid Dynamics-Model System for Advancing Tissue Engineering and Cancer Research Studies: Biological Assessment of the Innovative BioAxFlow Dynamic Culture Bioreactor
Giulia Gramigna, Federica Liguori, Ludovica Filippini, Maurizio Mastantuono, Michele Pistillo, Margherita Scamarcio, Alessia Mengoni, Antonella Lisi, Giuseppe Falvo D’Urso Labate, Mario Ledda, Felicia Carotenuto · 2025
Read A Fluid Dynamics-Model System for Advancing Tissue Engineering and Cancer Research Studies: Biological Assessment of the Innovative BioAxFlow Dynamic Culture Bioreactor by Giulia Gramigna, Federica Liguori, Ludovica Filippini, Maurizio Mastantuono, Michele Pistillo, Margherita Scamarcio, Alessia Mengoni, Antonella Lisi, Giuseppe Falvo D’Urso Labate, Mario Ledda, Felicia Carotenuto (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12731094.txt.
Description
Giulia Gramigna and co-authors tested a new cell culture device for tissue and cancer studies, in this 2025 paper. Most culture devices stir the fluid with moving parts. Their device instead uses the chamber shape to keep the fluid moving, so cells get a steady flow of food and growth signals.
Bone cancer cells grown on bone-like scaffolds in the device stuck and grew better than in still cultures. The cells spread more evenly across the scaffold, a key trait for working tissue models. They kept their bone-forming potential and their tumor traits, including growth signals for blood vessels. The authors offer the device for repair medicine and drug tests.
Catalog record
| CREATOR | Giulia Gramigna, Federica Liguori, Ludovica Filippini, Maurizio Mastantuono, Michele Pistillo, Margherita Scamarcio, Alessia Mengoni, Antonella Lisi, Giuseppe Falvo D’Urso Labate, Mario Ledda, Felicia Carotenuto |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 70 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |