Yeast NatB Regulates Cell Death of Bax-Expressing Cells
Joana P. Guedes, Filipa Mendes, Beatriz O. Machado, Stéphen Manon, Manuela Côrte-Real, Susana R. Chaves · 2025
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Description
Joana Guedes and co-authors published a study in 2025 on how a yeast protein-tagging complex controls death in cells carrying the human Bax protein. Bax drives cell death by opening the mitochondrial membrane, and its tagging at one end was little studied. Working in yeast that make human Bax, the team removed the complex's enzyme subunit.
Cells lacking the subunit died far more readily under acid stress. The death mode seemed to shift toward a regulated necrosis as recycling stalled. A protective partner protein also lost its shielding power without the subunit. The authors suggest the tagger tunes both death and survival proteins, with lessons for diseases of faulty cell death.
Catalog record
| CREATOR | Joana P. Guedes, Filipa Mendes, Beatriz O. Machado, Stéphen Manon, Manuela Côrte-Real, Susana R. Chaves |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 30 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |