Reversing the Irreversible: miRNA-Targeting Mesyl Phosphoramidate Oligonucleotides Restore Sensitivity to Cisplatin and Doxorubicin of KB-8-5 Epidermoid Carcinoma Cells
Svetlana Miroshnichenko, Rabia Demirel, Arseny Moralev, Olga Almieva, Andrey Markov, Ekaterina Burakova, Dmitry Stetsenko, Mikhail Maslov, Valentin Vlassov, Marina Zenkova, Jeong-yeon Lee, Fernando de Carvalho da Silva, Bruno Kaufmann Robbs · 2025
Read Reversing the Irreversible: miRNA-Targeting Mesyl Phosphoramidate Oligonucleotides Restore Sensitivity to Cisplatin and Doxorubicin of KB-8-5 Epidermoid Carcinoma Cells by Svetlana Miroshnichenko, Rabia Demirel, Arseny Moralev, Olga Almieva, Andrey Markov, Ekaterina Burakova, Dmitry Stetsenko, Mikhail Maslov, Valentin Vlassov, Marina Zenkova, Jeong-yeon Lee, Fernando de Carvalho da Silva, Bruno Kaufmann Robbs (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12730878.txt.
Description
Svetlana Miroshnichenko and co-authors test a way to make hard cancer cells drug-soft again in a 2025 study. Repeat chemo can breed cells that shrug off many drugs at once. The team aimed small blockers at three tiny RNA bits that help cells resist. The blockers use a new chemical build. Their test bed was a human skin cancer cell line bred to resist two core drugs, cisplatin and doxorubicin.
Pairs of blocker and drug worked as well as the sum of parts, and at times a touch more. With blockers in play, drug doses fell five to twenty-fold while cell kill held strong. A key drug-pump mark dropped in level. Three fresh marks tied to resistance also fell. The authors see the blockers as add-ons that could stretch old drugs. Cell tests come first here, so animal and human steps still lie ahead.
Catalog record
| CREATOR | Svetlana Miroshnichenko, Rabia Demirel, Arseny Moralev, Olga Almieva, Andrey Markov, Ekaterina Burakova, Dmitry Stetsenko, Mikhail Maslov, Valentin Vlassov, Marina Zenkova, Jeong-yeon Lee, Fernando de Carvalho da Silva, Bruno Kaufmann Robbs |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 73 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |