Synergistic Disruption of Survival and Metastatic Potential in Esophageal Adenocarcinoma Cells Through Combined Inhibition of HIF1α and CD73
Ian Mersich, Alexander Malmberg, Eahsanul Anik, Md Sazzad Hassan, Urs von Holzen, Brian S J Blagg, Aktar Ali, Shihori Tanabe · 2025
Read Synergistic Disruption of Survival and Metastatic Potential in Esophageal Adenocarcinoma Cells Through Combined Inhibition of HIF1α and CD73 by Ian Mersich, Alexander Malmberg, Eahsanul Anik, Md Sazzad Hassan, Urs von Holzen, Brian S J Blagg, Aktar Ali, Shihori Tanabe (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12730838.txt.
Description
Ian Mersich and co-authors studied two targets in a cancer of the food pipe, in a 2025 paper. Low oxygen in a tumor helps it grow, spread, and hide from the immune system. One protein switches on under low oxygen and turns up a second protein on the cell surface. The team asked how the two work as a pair and whether blocking both at once would do more harm to the cancer.
Gene and tissue checks linked high levels of the second protein to later stage disease and shorter survival. Blocking it alone cut cell survival only a little. Blocking both targets at once cut survival far more, above all under low oxygen. The pair block also slowed cell spread and cut signals that help new blood vessels form, which the authors see as a path worth testing further.
Catalog record
| CREATOR | Ian Mersich, Alexander Malmberg, Eahsanul Anik, Md Sazzad Hassan, Urs von Holzen, Brian S J Blagg, Aktar Ali, Shihori Tanabe |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 36 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |