Lynch Syndrome in Focus: A Multidisciplinary Review of Cancer Risk, Clinical Management, and Special Populations
Seyma Eroglu, Ilhan Birsenogul, Alexandra P. Bowen, Joseph F. Doyle, Stephen E. Pupkin, Joaquin Villar, Christopher M. Tarney, Edwin Gandia, Danielle M. Pastor, Juvianee I. Estrada-Veras · 2025
Read Lynch Syndrome in Focus: A Multidisciplinary Review of Cancer Risk, Clinical Management, and Special Populations by Seyma Eroglu, Ilhan Birsenogul, Alexandra P. Bowen, Joseph F. Doyle, Stephen E. Pupkin, Joaquin Villar, Christopher M. Tarney, Edwin Gandia, Danielle M. Pastor, Juvianee I. Estrada-Veras (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12730836.txt.
Description
Seyma Eroglu and co-authors review Lynch syndrome, the inherited defect that loads families with cancer risk, in this 2025 paper. Broken DNA repair genes let mutations pile up, raising the odds of bowel cancer and cancers of the womb, ovaries, and stomach. The review covers how the syndrome presents, its genetic underpinnings, and current management, with attention to special populations whose care needs differ. Screening colonoscopies and preventive surgery anchor the standard response.
Newer ground includes immunotherapy, to which these mutation-rich tumors often respond well. A multidisciplinary review serves the many clinics a single family touches: genetics, gastroenterology, gynecology, and oncology. Inherited risk only helps those who know they carry it, so the paper also serves cascade testing of relatives.
Catalog record
| CREATOR | Seyma Eroglu, Ilhan Birsenogul, Alexandra P. Bowen, Joseph F. Doyle, Stephen E. Pupkin, Joaquin Villar, Christopher M. Tarney, Edwin Gandia, Danielle M. Pastor, Juvianee I. Estrada-Veras |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 82 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |