Validation of proposals for definitions of moderate and severe disease activity in SLE: impact on flares, quality of life, damage accrual, hospitalisations and mortality
Irene Altabás-González, Iñigo Rua-Figueroa, Karen Roberts, Ivonne Lourdes Mamani, Coral Mouriño, Julia Martinez-Barrio, Maria Galindo Izquierdo, Jaime Calvo-Alén, Celia Erausquin, Belén Serrano-Benavente, Esther Uriarte, Eva Tomero, Mercedes Freire-González, Ricardo Blanco, Eva Salgado, Silvia Gómez · 2025
Read Validation of proposals for definitions of moderate and severe disease activity in SLE: impact on flares, quality of life, damage accrual, hospitalisations and mortality by Irene Altabás-González, Iñigo Rua-Figueroa, Karen Roberts, Ivonne Lourdes Mamani, Coral Mouriño, Julia Martinez-Barrio, Maria Galindo Izquierdo, Jaime Calvo-Alén, Celia Erausquin, Belén Serrano-Benavente, Esther Uriarte, Eva Tomero, Mercedes Freire-González, Ricardo Blanco, Eva Salgado, Silvia Gómez (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12730800.txt.
Description
Irene Altabás-González and a large team of co-authors test proposed definitions of moderate and severe lupus activity. Lupus, or SLE, flares and fades, and trials need shared lines for what counts as moderate or severe disease. Without them, studies cannot be compared and treatment rules stay vague. Their 2025 study takes draft definitions and checks them against real patient outcomes in a Spanish cohort. Flares, quality of life, organ damage, hospital stays, and death are the yardsticks.
A good definition should split patients whose futures truly differ. If the draft lines do that, registries and trials can adopt them with confidence. If not, the results show where to redraw. The authors frame validation as the step that turns expert opinion into a tool doctors can trust.
Catalog record
| CREATOR | Irene Altabás-González, Iñigo Rua-Figueroa, Karen Roberts, Ivonne Lourdes Mamani, Coral Mouriño, Julia Martinez-Barrio, Maria Galindo Izquierdo, Jaime Calvo-Alén, Celia Erausquin, Belén Serrano-Benavente, Esther Uriarte, Eva Tomero, Mercedes Freire-González, Ricardo Blanco, Eva Salgado, Silvia Gómez |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 41 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |