Pioglitazone Modulates p65-Mediated Mitochondrial Bioenergetics: Implications for Acetaldehyde-Induced HIV Replication in Alveolar Macrophages
Moses New-Aaron, Sarah Chang, Xian Fan, Ashish Mehta, Sara C Auld, Bashar S Staitieh, Michael Koval, Samantha M Yeligar, Dennis R Grayson · 2025
Read Pioglitazone Modulates p65-Mediated Mitochondrial Bioenergetics: Implications for Acetaldehyde-Induced HIV Replication in Alveolar Macrophages by Moses New-Aaron, Sarah Chang, Xian Fan, Ashish Mehta, Sara C Auld, Bashar S Staitieh, Michael Koval, Samantha M Yeligar, Dennis R Grayson (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12730783.txt.
Description
Moses New-Aaron and co-authors studied how a diabetes drug might curb HIV activity in lung immune cells exposed to alcohol breakdown products, in a 2025 paper. Alcohol misuse is twice as common in people living with HIV and raises lung risks even on treatment. Past work by the team showed that acetaldehyde, the main alcohol breakdown product, switches on a gene regulator that drives HIV copying in lung macrophages.
That copying and the release of an inflammatory signal both demand energy, and they strain cell power units. In mouse lung macrophages, the alcohol product plus a model HIV raised power unit activity, leaks, and damaging oxygen species. A drug that blocks energy making lowered both HIV copying and the inflammatory signal. The diabetes drug pioglitazone, which quiets the same regulator, curbed the energy surge, the oxygen damage, and both HIV and inflammatory outputs.
Catalog record
| CREATOR | Moses New-Aaron, Sarah Chang, Xian Fan, Ashish Mehta, Sara C Auld, Bashar S Staitieh, Michael Koval, Samantha M Yeligar, Dennis R Grayson |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 63 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |