TRIM14 Regulation of Copper Homeostasis and Cuproptosis: A New Strategy to Overcome Chemoresistance in Glioblastoma
Jianyong Wang, Enhao Zhang, Siqi Chen, Haifeng Wang, Yi Huang, Wenting Lan · 2025
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Description
Glioblastoma shrugs off the standard chemotherapy drug temozolomide, and resistance is the usual story within months. Jianyong Wang and co-authors explore a newer way to kill these tumor cells in 2025: cuproptosis, death by copper overload. They ask how a protein called TRIM14 and its partner, a copper pump, govern the cell's copper balance.
Drug plus copper chloride together flooded glioma cells with copper and triggered the death pathway, while switching the TRIM14 axis down. Tests in dishes and mouse tumors supported the mechanism. The authors propose blocking that axis to restore copper-driven death as a strategy against drug-resistant glioblastoma, a cancer badly in need of new angles.
Catalog record
| CREATOR | Jianyong Wang, Enhao Zhang, Siqi Chen, Haifeng Wang, Yi Huang, Wenting Lan |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 53 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |