The Impact of Sex Hormones on Transcranial Magnetic Stimulation Against the Oxidative Stress in the Pathogenesis of Multiple Sclerosis
Begoña M Escribano, Manuel E Valdevira, Ana Muñoz-Jurado, Montse Feijóo, Eduardo Agüera, Javier Caballero-Villarraso, Manuel LaTorre, Ana I Giraldo, Abel Santamaría, Isaac Túnez, Fabio Di Domenico · 2025
Read The Impact of Sex Hormones on Transcranial Magnetic Stimulation Against the Oxidative Stress in the Pathogenesis of Multiple Sclerosis by Begoña M Escribano, Manuel E Valdevira, Ana Muñoz-Jurado, Montse Feijóo, Eduardo Agüera, Javier Caballero-Villarraso, Manuel LaTorre, Ana I Giraldo, Abel Santamaría, Isaac Túnez, Fabio Di Domenico (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12730606.txt.
Description
Begoña Escribano and co-authors tested whether sex hormones change how magnetic brain stimulation fights oxidative stress in a rat model of multiple sclerosis. The disease is an immune attack on the nervous system and strikes women more often than men. The team used the standard animal model and gave some rats estrogen, progesterone, or testosterone alongside the stimulation. Other rats had their ovaries removed and got hormone replacement instead.
Stimulation alone already eased the oxidative damage from the disease. In the ovary-removed rats, estrogen and progesterone replacement boosted the effect, waking up antioxidant defenses and softening clinical signs. Testosterone did not show the same help. The authors suggest that pairing stimulation with the right hormone therapy could strengthen treatment, at least in this animal setting. Human work would need to follow.
Catalog record
| CREATOR | Begoña M Escribano, Manuel E Valdevira, Ana Muñoz-Jurado, Montse Feijóo, Eduardo Agüera, Javier Caballero-Villarraso, Manuel LaTorre, Ana I Giraldo, Abel Santamaría, Isaac Túnez, Fabio Di Domenico |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 43 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |