The Cx43-Mediated Autophagy Mechanism Influences Triple-Negative Breast Cancer Through the Regulation of Rab31
Jiao Yang, Die Wu, Ting Yang, Zi-Jing Lin, Pei-Yao Jiang, Ting-Rui Wang, Zheng-Jia Lu, Lu Wang, Jia Ming, Paola Marcato · 2025
Read The Cx43-Mediated Autophagy Mechanism Influences Triple-Negative Breast Cancer Through the Regulation of Rab31 by Jiao Yang, Die Wu, Ting Yang, Zi-Jing Lin, Pei-Yao Jiang, Ting-Rui Wang, Zheng-Jia Lu, Lu Wang, Jia Ming, Paola Marcato (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12730575.txt.
Description
Jiao Yang and co-authors trace how a cell-surface linker protein shapes the most aggressive breast cancer type. The cancer lacks the usual hormone and growth receptors, so drug options are few. The protein's exact role in it was unclear.
The team mined expression data from over sixty breast cancer cell lines and patient tissues. Raising or lowering the protein in two cancer cell lines changed growth, spread, and self-eating behavior. A partner protein was found that binds the linker and carries much of the effect. Self-eating proteins shifted in step with the pair. The chain offers new drug targets in a cancer short of them. Lab evidence is the first rung, and the authors treat it so.
Catalog record
| CREATOR | Jiao Yang, Die Wu, Ting Yang, Zi-Jing Lin, Pei-Yao Jiang, Ting-Rui Wang, Zheng-Jia Lu, Lu Wang, Jia Ming, Paola Marcato |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 52 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |