Fucoidan Therapy for Extraintestinal Diseases: Targeting the Microbiota–Gut–Organ Axes
Xian Sun, Ping Li, Baoduan Chen, Chong Chen, Jing Zhao, Sifan Sun, Stefan G Pierzynowski, Bart A Ellenbroek · 2025
Read Fucoidan Therapy for Extraintestinal Diseases: Targeting the Microbiota–Gut–Organ Axes by Xian Sun, Ping Li, Baoduan Chen, Chong Chen, Jing Zhao, Sifan Sun, Stefan G Pierzynowski, Bart A Ellenbroek (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12730560.txt.
Description
Xian Sun and co-authors review a seaweed sugar that treats distant organs by gardening the gut. Fucoidans, sulfated polysaccharides found only in brown seaweeds, reshape the gut microbiota toward helpful species and away from harmful ones. The downstream chemistry changes with them: more short-chain fatty acids and good bile acids, less inflammatory bacterial toxin.
Barrier integrity in the gut wall recovers as well. Through the microbiota-gut-organ axes, benefits surface in models of Parkinson's disease, alcoholic liver disease, diabetic kidney disease, and obesity, and transplant experiments confirm the microbes carry the effect. The authors present fucoidans as prebiotic candidates for diseases far from the gut, while noting human trials still lag the animal evidence.
Catalog record
| CREATOR | Xian Sun, Ping Li, Baoduan Chen, Chong Chen, Jing Zhao, Sifan Sun, Stefan G Pierzynowski, Bart A Ellenbroek |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 86 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |