Propofol-Induced Mitochondrial Dysfunction Is Independent of Mitochondrial Permeability Transition
Aya Kawachi, Shoichiro Shibata, Eskil Elmér, Hiroyuki Uchino · 2025
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Description
Sedatives used in intensive care have been suspected of harming the brain by sabotaging its mitochondria. Aya Kawachi and co-authors tested in 2025 three common sedatives on mouse brain mitochondria to see which, if any, do the damage.
Only propofol, at high doses, cut the organelles' breathing capacity and made them swell. A natural suspect was a pore whose opening wrecks mitochondria, but mitochondria from mice lacking that pore's key protein suffered just the same. Nor did the drug trigger release of a death signal protein. The authors conclude propofol's mitochondrial harm travels a different route than the classic pore pathway.
Catalog record
| CREATOR | Aya Kawachi, Shoichiro Shibata, Eskil Elmér, Hiroyuki Uchino |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 25 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |