Potential Role of the Glycogen-Targeting Phosphatase Regulatory Subunit in Airway Hyperresponsiveness in Asthma
Marisol Alvarez-González, Elizabeth Eslava-De Jesús, Blanca Bazan-Perkins, Alberto Ricci · 2025
Read Potential Role of the Glycogen-Targeting Phosphatase Regulatory Subunit in Airway Hyperresponsiveness in Asthma by Marisol Alvarez-González, Elizabeth Eslava-De Jesús, Blanca Bazan-Perkins, Alberto Ricci (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12730424.txt.
Description
Alvarez-González and co-authors look for proteins in airway muscle that may drive the twitchiness of airways in asthma. Airway hyperresponsiveness is a hallmark of the disease, but its molecular roots are still unclear. Working in guinea pigs with an induced allergic asthma model, the team measured airway response to histamine and analyzed tracheal tissue proteins with mass spectrometry. One known suspect protein was not found; instead, a peptide from a glycogen-targeting regulatory subunit, RG1, turned up.
Follow-up staining showed RG1 and a partner kinase, ROCK2, were both raised in the airway muscle of the asthma model, and their levels tracked the degree of hyperresponsiveness. The two proteins' levels also correlated with each other. The authors suggest RG1 may help drive the overreaction of asthmatic airways. As an animal study, the work points to a candidate mechanism rather than proving one in patients.
Catalog record
| CREATOR | Marisol Alvarez-González, Elizabeth Eslava-De Jesús, Blanca Bazan-Perkins, Alberto Ricci |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 38 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |