Oncolytic Viruses in Glioblastoma: Clinical Progress, Mechanistic Insights, and Future Therapeutic Directions
Jiayu Liu, Yuxin Wang, Shichao Su, Gang Cheng, Hulin Zhao, Junzhao Sun, Guochen Sun, Fangye Li, Rui Hui, Meijing Liu, Lin Wu, Dongdong Wu, Fan Yang, Yuanyuan Dang, Junru Hei, Yanteng Li, Zhao Gao, Bingxian Wang, Yunjuan Bai, Wenying Lv, Jianning Zhang · 2025
Read Oncolytic Viruses in Glioblastoma: Clinical Progress, Mechanistic Insights, and Future Therapeutic Directions by Jiayu Liu, Yuxin Wang, Shichao Su, Gang Cheng, Hulin Zhao, Junzhao Sun, Guochen Sun, Fangye Li, Rui Hui, Meijing Liu, Lin Wu, Dongdong Wu, Fan Yang, Yuanyuan Dang, Junru Hei, Yanteng Li, Zhao Gao, Bingxian Wang, Yunjuan Bai, Wenying Lv, Jianning Zhang (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12730407.txt.
Description
Glioblastoma shrugs off surgery, radiation, and chemotherapy, with typical survival near fifteen months. Jiayu Liu and co-authors review a different weapon in a 2025 paper: viruses engineered to infect and burst tumor cells while waking up the immune system.
Trials of several virus families are surveyed, led by a herpes-based entry already approved in Japan for recurrent disease. One adenovirus program pairs the virus with an immune checkpoint drug in multi-center trials. Other families remain at early stages. Benefits seem strongest when viruses team with standard drugs, yet delivery across the blood-brain barrier and the tumor's immune suppression still block progress. The review closes with design ideas, from programmable viruses to better patient matching.
Catalog record
| CREATOR | Jiayu Liu, Yuxin Wang, Shichao Su, Gang Cheng, Hulin Zhao, Junzhao Sun, Guochen Sun, Fangye Li, Rui Hui, Meijing Liu, Lin Wu, Dongdong Wu, Fan Yang, Yuanyuan Dang, Junru Hei, Yanteng Li, Zhao Gao, Bingxian Wang, Yunjuan Bai, Wenying Lv, Jianning Zhang |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 42 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |