Arteriovenous Malformations (AVMs): Molecular Pathogenesis, Clinical Features, and Emerging Therapeutic Strategies
Nga Le, Yan Li, Gianni Walker, Bao-Ngoc Nguyen, Arash Bornak, Sapna K Deo, Omaida C Velazquez, Zhao-Jun Liu, Vincenzo Brancaleone · 2025
Read Arteriovenous Malformations (AVMs): Molecular Pathogenesis, Clinical Features, and Emerging Therapeutic Strategies by Nga Le, Yan Li, Gianni Walker, Bao-Ngoc Nguyen, Arash Bornak, Sapna K Deo, Omaida C Velazquez, Zhao-Jun Liu, Vincenzo Brancaleone (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12730398.txt.
Description
A peer-reviewed research article from Europe PMC (2025). Arteriovenous malformations (AVMs) are fast-flow vascular malformations formed by direct artery-to-vein shunts without an intervening capillary bed, which increases the risk of hemorrhage and organ-specific damage. A synthesis of recent advances shows that AVMs arise from interplay between germline susceptibility (ENG, ACVRL1, SMAD4, RASA1, EPHB4), somatic mosaicism (KRAS, MAP2K1, PIK3CA), perturbed signaling (TGF-β/BMP, Notch, VEGF, PI3K/AKT, RAS/MAPK), hemodynamic stress, and inflammation.
Catalog record
| CREATOR | Nga Le, Yan Li, Gianni Walker, Bao-Ngoc Nguyen, Arash Bornak, Sapna K Deo, Omaida C Velazquez, Zhao-Jun Liu, Vincenzo Brancaleone |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 50 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |