Leukemic Transdifferentiation: From Pathological Plasticity to Dendritic Cell-Based Immunotherapy
Joanna Dubis, Aleksander Czogalla, Kazimierz Kuliczkowski, Aleksander F Sikorski, Myunggon Ko · 2025
Read Leukemic Transdifferentiation: From Pathological Plasticity to Dendritic Cell-Based Immunotherapy by Joanna Dubis, Aleksander Czogalla, Kazimierz Kuliczkowski, Aleksander F Sikorski, Myunggon Ko (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12730332.txt.
Description
Joanna Dubis and co-authors review how leukemia cells can be coaxed to change into immune cells that show off cancer parts to the body. Their 2025 paper calls the shift transdifferentiation: a mature cell turns into a different mature kind without going back to a stem state. In leukemia the same trick cuts both ways.
On one side, the shift helps tumors dodge drugs and survive. On the other, steering it toward dendritic cells, the immune system's scouts, makes the cancer easier to spot and attack. The review gathers what is known of the switch's wiring, then covers lab and animal methods to force it, and the therapies that might grow from them.
Catalog record
| CREATOR | Joanna Dubis, Aleksander Czogalla, Kazimierz Kuliczkowski, Aleksander F Sikorski, Myunggon Ko |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 68 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |