A Mathematical Model for the Variation of Cerebral Electrical Conductivity and the Amount of β-Amyloid Protein Values Due to Alzheimer’s Disease
Emmanouil Perakis, Panagiotis Vlamos, Fanglin Guan · 2025
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Description
Alzheimer's disease builds up a sticky protein, amyloid-beta, in the brain while the tissue's electrical conductivity fades. Emmanouil Perakis and Panagiotis Vlamos model that twin decline in a 2025 paper. Their aim is a compact math picture that links the early chemical change to the later loss of brain function.
The model joins two time-bound processes: the protein load grows toward a high plateau, and conductivity falls after a delay toward an impaired floor. In simulations the pair shows the slow, one-way drop in cortical conductivity that clinical studies report, and the strong inverse link between protein burden and electrical health. The authors keep the model deliberately small so it can be read and extended. They suggest adding tau protein, inflammation, or spatial variation as next steps.
Catalog record
| CREATOR | Emmanouil Perakis, Panagiotis Vlamos, Fanglin Guan |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 39 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |