Inactivated Type ‘O’ Foot and Mouth Disease Virus Encapsulated in Chitosan Nanoparticles Induced Protective Immune Response in Guinea Pigs
Kalaivanan Ramya, Subodh Kishore, Palanisamy Sankar, Ganesh Kondabatulla, Bedaso Mamo Edao, Ramasamy Saravanan, Kumaraguruban Karthik · 2025
Read Inactivated Type ‘O’ Foot and Mouth Disease Virus Encapsulated in Chitosan Nanoparticles Induced Protective Immune Response in Guinea Pigs by Kalaivanan Ramya, Subodh Kishore, Palanisamy Sankar, Ganesh Kondabatulla, Bedaso Mamo Edao, Ramasamy Saravanan, Kumaraguruban Karthik (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12729774.txt.
Description
Kalaivanan Ramya and co-authors wrap a killed foot-and-mouth disease virus in chitosan nanoparticles to build a better vaccine. Their 2025 study tests the formulation in guinea pigs, given through the nose or by injection. Standard vaccines protect briefly and stir little immunity at the nose and mouth, where the virus enters.
The particles carried a good antigen load and released it steadily. Nose dosing raised mucosal antibodies, while injection raised stronger blood responses. After challenge with live virus, the injected nanoparticle group was protected best, at about eighty-eight percent. The nose group and standard vaccine groups followed at about seventy-eight percent. No side effects appeared, supporting chitosan as a delivery vehicle.
Catalog record
| CREATOR | Kalaivanan Ramya, Subodh Kishore, Palanisamy Sankar, Ganesh Kondabatulla, Bedaso Mamo Edao, Ramasamy Saravanan, Kumaraguruban Karthik |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 43 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |