The ratio of omega-6 fatty acids to omega-3 fatty acids mediating the effect of gastroesophageal reflux disease on pancreatic cancer risk: a two-step mediation Mendelian randomisation study
Jiqi Ouyang, Runshun Zhang, Wenliang Lv, Yanping Lu · 2025
Read The ratio of omega-6 fatty acids to omega-3 fatty acids mediating the effect of gastroesophageal reflux disease on pancreatic cancer risk: a two-step mediation Mendelian randomisation study by Jiqi Ouyang, Runshun Zhang, Wenliang Lv, Yanping Lu (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12729688.txt.
Description
Jiqi Ouyang and co-authors use gene based methods to test whether reflux disease raises the risk of pancreatic cancer, and whether fat balance in the blood links the two. Pancreatic cancer kills many patients, with five year survival near 9 to 10 percent in rich countries. Past work on reflux and this cancer clashed.
Their 2025 study uses Mendelian randomisation, which treats gene variants as natural tests of cause. Reflux raised cancer risk in their data, with an odds ratio of 2.07. Reflux also raised the ratio of omega-6 to omega-3 fats, and that ratio raised cancer risk too. A second stage weighed how much of the effect runs through the fats.
Catalog record
| CREATOR | Jiqi Ouyang, Runshun Zhang, Wenliang Lv, Yanping Lu |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 45 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |