Luteolin in Safflower Leaves Suppresses Microglial Inflammation Through FOXO3-Mediated Trem2 Transcription
Tiantian Zhang, Shuangxi Zhang, Jiayang Ma, Dmitrii Atiakshin, Shujun Han, Mami Noda, Midori Hiramatsu, Jiankang Liu, Yunhua Peng, Jiangang Long · 2025
Read Luteolin in Safflower Leaves Suppresses Microglial Inflammation Through FOXO3-Mediated Trem2 Transcription by Tiantian Zhang, Shuangxi Zhang, Jiayang Ma, Dmitrii Atiakshin, Shujun Han, Mami Noda, Midori Hiramatsu, Jiankang Liu, Yunhua Peng, Jiangang Long (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12729663.txt.
Description
Brain inflammation driven by microglia, the brain's immune cells, is a hallmark of Alzheimer's disease, and a protein called TREM2 helps keep that inflammation in check. A ten-author team studied safflower leaves, a vegetable rich in the compound luteolin, building on hints that the leaves calm brain inflammation in mice bred to develop Alzheimer's-like changes.
In those mice, leaf treatment raised TREM2 levels and quieted microglia. In cell tests, luteolin alone did the same. The team traced the effect to a switch protein, FOXO3, which turns on the Trem2 gene once luteolin moves it into the cell nucleus. They report FOXO3 as a newly found regulator of that gene. When Trem2 was knocked down, luteolin's calming effect faded, confirming the pathway's role. The authors propose the leaves or their key compound as a dietary candidate worth further study.
Catalog record
| CREATOR | Tiantian Zhang, Shuangxi Zhang, Jiayang Ma, Dmitrii Atiakshin, Shujun Han, Mami Noda, Midori Hiramatsu, Jiankang Liu, Yunhua Peng, Jiangang Long |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 30 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |