Advances in Silicone Implants Characterization: A Comprehensive Overview of Chemical, Physical and Biological Methods for Biocompatibility Assessment
Kevin Dzobo, Nonhlanhla Khumalo, Vanessa Zamora Mora, Audry Zoncsich, Roberto de Mezerville, Ardeshir Bayat · 2025
Read Advances in Silicone Implants Characterization: A Comprehensive Overview of Chemical, Physical and Biological Methods for Biocompatibility Assessment by Kevin Dzobo, Nonhlanhla Khumalo, Vanessa Zamora Mora, Audry Zoncsich, Roberto de Mezerville, Ardeshir Bayat (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12729539.txt.
Description
Kevin Dzobo and co-authors published this review in 2025. Silicone implants, above all breast implants, are used worldwide for reconstruction and augmentation. Doubts about their long-term safety persist, so how they are tested matters. Standard biocompatibility protocols follow a one-size-fits-all template that ignores implant type and exposure time. The review surveys the full testing toolbox across chemistry, physics, and biology, and argues for assessments tailored to each application.
Chemical spectroscopy checks the polymer's structure and purity. Microscopy and surface measurements reveal defects and water behavior that shape the body's response. Mechanical tests simulate years of stress to forecast durability. Cell and animal studies measure toxicity, inflammation, and tissue integration. Newer options include organ-on-chip systems and machine learning predictors. The authors propose a modular standard that merges all three testing families with real clinical data, aiming at safer implants and clearer regulation.
Catalog record
| CREATOR | Kevin Dzobo, Nonhlanhla Khumalo, Vanessa Zamora Mora, Audry Zoncsich, Roberto de Mezerville, Ardeshir Bayat |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 127 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |