Probiotic Lactobacillus reuteri Y7 Protects Against Blue Light–Induced Retinal Degeneration via Antioxidant Defense, Anti-Inflammatory Action, and Gut–Retina Axis Modulation
Shu-Ping Tsao, Tu-Hsueh Yeh, Tsung-Jen Wang, Keita Nishiyama, Chun-Hsu Pan, Chih-Hsuan Lou, Hui-Yu Huang, Alessandra Napolitano, Ram Kannan · 2025
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Description
A peer-reviewed research article from Europe PMC (2025). Chronic exposure to short-wavelength blue light induces oxidative stress, inflammation, and apoptosis in retinal tissues, contributing to vision loss. This study investigated the protective effects of Lactobacillus reuteri Y7, a human-derived probiotic, against blue light–induced retinal damage in mice. Male C57BL/6 mice were exposed to 400 lux blue light for 35 days and received either low- or high-dose Y7, lutein, or no intervention. Retinal morphology, inflammatory gene expression, gut barrier integrity, and gut microbiota composition were assessed.
Catalog record
| CREATOR | Shu-Ping Tsao, Tu-Hsueh Yeh, Tsung-Jen Wang, Keita Nishiyama, Chun-Hsu Pan, Chih-Hsuan Lou, Hui-Yu Huang, Alessandra Napolitano, Ram Kannan |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 70 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |