Photobiomodulation mitigates chondrocyte catabolism in osteoarthritis by modulating macrophage M1 polarization through the IL-6/JAK/STAT pathway
Haiming Wang, Wenhua Ning, Yiying Liu, Jing Nie, Shenao Du, Haowei Zhang · 2025
Read Photobiomodulation mitigates chondrocyte catabolism in osteoarthritis by modulating macrophage M1 polarization through the IL-6/JAK/STAT pathway by Haiming Wang, Wenhua Ning, Yiying Liu, Jing Nie, Shenao Du, Haowei Zhang (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12729256.txt.
Description
Haiming Wang and five co-authors test whether light therapy can slow osteoarthritis by calming immune cells in the joint. Their 2025 study starts from the fact that this joint disease wears down cartilage and inflames the tissue lining the joint. Immune cells called macrophages help drive that damage when they take an inflammatory form.
The team combined single-cell and bulk gene data to find the key cells and pathways, and one pathway stood out. In cell cultures, the light treatment helped cartilage cells grow, cut their breakdown, and kept macrophages from switching to the inflammatory form. In mice with the disease, the treatment eased cartilage damage and joint lining growth. Both sets of tests point to the same pathway as the route of action. The authors present light therapy as a drug-free option worth further study.
Catalog record
| CREATOR | Haiming Wang, Wenhua Ning, Yiying Liu, Jing Nie, Shenao Du, Haowei Zhang |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 50 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |