Efficacy of melflufen in multiple myeloma with mutated or deleted TP53
Klara Acs, Juho J. Miettinen, Philipp Sergeev, Tobias Heckel, Yumei Diao, Kristina Witt-Mulder, Marcus Thureson, Thorsten Bischler, Maiju-Emilia Huppunen, Minna Suvela, Jakob Obermüller, Umair Munawar, Ana Slipicevic, Ralf C. Bargou, Fredrik Lehmann, Stefan Svensson Gelius, Stefan Norin, Fredrik Sch · 2025
Read Efficacy of melflufen in multiple myeloma with mutated or deleted TP53 by Klara Acs, Juho J. Miettinen, Philipp Sergeev, Tobias Heckel, Yumei Diao, Kristina Witt-Mulder, Marcus Thureson, Thorsten Bischler, Maiju-Emilia Huppunen, Minna Suvela, Jakob Obermüller, Umair Munawar, Ana Slipicevic, Ralf C. Bargou, Fredrik Lehmann, Stefan Svensson Gelius, Stefan Norin, Fredrik Sch (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12729255.txt.
Description
Klara Acs and co-authors test a myeloma drug in cancers that lack a key tumour suppressor, in a 2025 study. Multiple myeloma patients whose cancer has lost or mutated the TP53 gene, often via a missing chromosome piece, fare worse than others. The drug, melflufen, delivers a cell-killing payload into cancer cells.
In lab tests on patient cells, the drug worked as well on cells with the gene loss as on normal cells. Single-cell gene data showed that sensitive cells had low levels of the suppressor target genes and high repair and checkpoint genes. The drug caused cell death, DNA damage, and energy failure whatever the gene state was. A later look at a clinical trial found patients with the gene loss on this drug did better than a rival drug group. The authors support its use in that hard group.
Catalog record
| CREATOR | Klara Acs, Juho J. Miettinen, Philipp Sergeev, Tobias Heckel, Yumei Diao, Kristina Witt-Mulder, Marcus Thureson, Thorsten Bischler, Maiju-Emilia Huppunen, Minna Suvela, Jakob Obermüller, Umair Munawar, Ana Slipicevic, Ralf C. Bargou, Fredrik Lehmann, Stefan Svensson Gelius, Stefan Norin, Fredrik Sch |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 12 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |