Bambi/Akt/Tlr4 axis protects against atherosclerosis by maintaining lipid metabolism homeostasis in macrophages
Xiaochang Chen, Siyu Tan, Siting Li, Peihong Su, Hua Guan, Aoqi Xiang, Lusha Zhang, Haoping Wang, Qi Yu · 2025
Read Bambi/Akt/Tlr4 axis protects against atherosclerosis by maintaining lipid metabolism homeostasis in macrophages by Xiaochang Chen, Siyu Tan, Siting Li, Peihong Su, Hua Guan, Aoqi Xiang, Lusha Zhang, Haoping Wang, Qi Yu (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12729244.txt.
Description
Xiaochang Chen and colleagues test a gene that may guard arteries against plaque, in this study from twenty twenty-five. The gene makes Bambi, a decoy receptor that blunts a family of growth signals. Plaque grows when artery walls inflame and when scavenger cells called macrophages gorge on cholesterol and turn into foam cells.
The team gave extra Bambi to mice bred to form plaque, then fed them a fatty diet for fourteen weeks. Their artery plaques shrank, and their macrophages shifted from an angry state to a calm one, with key inflammation signals falling. In lab dishes, Bambi helped macrophages export cholesterol and resist turning into foam cells. Gene scans traced the effect to a chain: Bambi wakes a signal called Akt, which lowers a germ sensor, TLR4. The authors propose Bambi as a fresh target for drugs against clogged arteries.
Catalog record
| CREATOR | Xiaochang Chen, Siyu Tan, Siting Li, Peihong Su, Hua Guan, Aoqi Xiang, Lusha Zhang, Haoping Wang, Qi Yu |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 47 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |