Biomimetic dual-crosslinked GelMA-SilMA hydrogel microneedle for delivering DSPE-PEG2K-TAT-modified quercetin liposomes to treat rheumatoid arthritis via the caspase-8/caspase-3/GSDME pathway
Qingcong Zheng, Rongjie Lin, Rongsheng Chen, Weihong Xu · 2025
Read Biomimetic dual-crosslinked GelMA-SilMA hydrogel microneedle for delivering DSPE-PEG2K-TAT-modified quercetin liposomes to treat rheumatoid arthritis via the caspase-8/caspase-3/GSDME pathway by Qingcong Zheng, Rongjie Lin, Rongsheng Chen, Weihong Xu (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12729175.txt.
Description
Qingcong Zheng, Rongjie Lin, Rongsheng Chen, and Weihong Xu built a microneedle patch against rheumatoid arthritis in this 2025 paper. The disease inflames joints, driven in part by aggressive synovial cells in the joint lining. A fiery form of cell death, pyroptosis, runs through a chain of enzymes in those cells and fuels the damage.
The patch is a dissolvable hydrogel needle array, printed in three dimensions from two modified natural gels. Its needles carry tiny fat bubbles loaded with quercetin, a plant compound, wrapped to slip into target cells. Pressed on skin over a joint, the needles melt and release their cargo. The cargo aims at the first enzyme in the death chain. The design seeks strong local treatment with fewer whole-body side effects than pills.
Catalog record
| CREATOR | Qingcong Zheng, Rongjie Lin, Rongsheng Chen, Weihong Xu |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 106 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |