Identification of potential characteristic genes in sepsis utilizing RNA sequencing and gene silence
Hongying Cao, Nianying Qin, Yiling Zhai, Chunyang Dong, Zhou Huang, Dongling Huang, Jincheng Li, Jie Yang, Fan Wang, Wanxia Wei, Wei Wang · 2025
Read Identification of potential characteristic genes in sepsis utilizing RNA sequencing and gene silence by Hongying Cao, Nianying Qin, Yiling Zhai, Chunyang Dong, Zhou Huang, Dongling Huang, Jincheng Li, Jie Yang, Fan Wang, Wanxia Wei, Wei Wang (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12729154.txt.
Description
Hongying Cao and co-authors search blood gene data for marker genes that could help identify and understand sepsis, published in 2025. Sepsis is a life-threatening failure of organs in response to infection. Death rates run high, and rise further in severe cases and septic shock.
The team sequenced genes in blood from sepsis patients and healthy volunteers. Computer analysis, lab tests, and a meta-analysis were used to pick out genes that differ in sepsis. They then checked single-cell data to locate where those genes act. A sepsis cell model, gene silencing, and a protein test were used to validate the markers and gauge inflammatory factors. The goal is a set of candidate genes tied to how sepsis affects the immune system.
Catalog record
| CREATOR | Hongying Cao, Nianying Qin, Yiling Zhai, Chunyang Dong, Zhou Huang, Dongling Huang, Jincheng Li, Jie Yang, Fan Wang, Wanxia Wei, Wei Wang |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |