Distilling the evidence for GLP-1 receptor agonists in alcohol use disorder
Eden Y Bernstein, Joseph P Schacht · 2025
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Description
Eden Bernstein and Joseph Schacht weighed in 2025 the evidence that GLP-1 receptor agonists, drugs used for diabetes and obesity, might help treat alcohol use disorder. Current approved drugs work, but only modestly, and many patients gain little. Early reports raised hope that these newer drugs could cut drinking.
They discuss a review that pooled six observational studies and three randomized trials. The observational work linked the drugs to fewer alcohol-related events, but such designs cannot rule out hidden bias. The trials, pooled, showed no clear effect, though two single trials found real drops in drinking. The authors urge larger trials before strong claims are made, while noting grounds for hope.
Catalog record
| CREATOR | Eden Y Bernstein, Joseph P Schacht |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 7 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |