Postnatal dexamethasone treatment for preterm infants at high risk for bronchopulmonary dysplasia is associated with improved regional brain volumes: a prospective cohort study
Rahul Chandwani, Julia Kline, Mekibib Altaye, Nehal Parikh · 2025
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Description
Rahul Chandwani and colleagues find that steroid treatment for premature infants at high lung disease risk associates with larger regional brain volumes. Their 2025 prospective cohort study follows nearly four hundred infants born at or before thirty-two weeks.
Brain scans at term-equivalent age were segmented automatically to measure cerebellum and deep grey matter volumes. Forty-one infants received low-dose dexamethasone starting at a median of thirty-six days for evolving lung disease. Statistical weighting balanced treated and untreated groups. Treated infants showed significantly larger cerebellar and deep grey matter volumes in adjusted models. Secondary outcomes covered cortical surface area and motor scores at two years corrected age.
Catalog record
| CREATOR | Rahul Chandwani, Julia Kline, Mekibib Altaye, Nehal Parikh |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 34 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |