Enzyme-driven triplex structure-based DNA logic circuits
Xiao Liu, Jing Zhang, Xuehao Zhang, Zhuo Chen, Shize Zhang, Xinyu Wang, Jiaying Liu, Zhiheng Wang, Liyi Xie, Zhihao Ming, Longjie Li, Kaixiong Tao, Xianjin Xiao, Xiaoyu Zhou, Yu Xie · 2025
Read Enzyme-driven triplex structure-based DNA logic circuits by Xiao Liu, Jing Zhang, Xuehao Zhang, Zhuo Chen, Shize Zhang, Xinyu Wang, Jiaying Liu, Zhiheng Wang, Liyi Xie, Zhihao Ming, Longjie Li, Kaixiong Tao, Xianjin Xiao, Xiaoyu Zhou, Yu Xie (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12729061.txt.
Description
Xiao Liu and co-authors build DNA logic circuits driven by enzymes and triple-strand locks in a 2025 paper. DNA circuits compute with molecules, suiting sensing and smart materials, but leaks and fading signals cap their size. Enzyme-driven designs run faster with less leak, yet still fade in deep chains.
Joining inputs and gates into triple-strand forms trims strand design and leak. A sturdy polymerase powers the steps, finishing single gates in under two minutes. Chains of gates and a ten-gate square root circuit ran fast with fewer strands than past designs. The team sees modular growth for bio-computing networks.
Catalog record
| CREATOR | Xiao Liu, Jing Zhang, Xuehao Zhang, Zhuo Chen, Shize Zhang, Xinyu Wang, Jiaying Liu, Zhiheng Wang, Liyi Xie, Zhihao Ming, Longjie Li, Kaixiong Tao, Xianjin Xiao, Xiaoyu Zhou, Yu Xie |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 29 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |