Synchronous malignant tumors of the larynx with various histogenesis: leiomyosarcoma and squamous cell carcinoma—A case report
Olga V. Cheremisina, Sergey V. Vtorushin, Marina V. Vusik, Denis E. Kulbakin, Sergei S. Naumov, Nadezhda V. Krakhmal · 2025
Read Synchronous malignant tumors of the larynx with various histogenesis: leiomyosarcoma and squamous cell carcinoma—A case report by Olga V. Cheremisina, Sergey V. Vtorushin, Marina V. Vusik, Denis E. Kulbakin, Sergei S. Naumov, Nadezhda V. Krakhmal (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12729008.txt.
Description
Two cancers in one throat is rare; two cancers of different tissue families in one larynx is rarer still. Olga Cheremisina and co-authors report such a case in a 2025 paper. Their patient, a sixty-six-year-old man, carried a well-differentiated squamous cell carcinoma on the right vocal fold. Below it sat a high-grade leiomyosarcoma, a smooth-muscle cancer with fewer than fifty laryngeal cases ever reported.
Endoscopy, tissue study, and antibody staining separated the two diseases. Treatment was total laryngectomy with a permanent breathing opening in the neck, followed by radiotherapy. Follow-up found no recurrence. The authors use the case to argue for full multimodal workup when a laryngeal tumor looks unusual, since the rarer partner changes both the operation and the outlook.
Catalog record
| CREATOR | Olga V. Cheremisina, Sergey V. Vtorushin, Marina V. Vusik, Denis E. Kulbakin, Sergei S. Naumov, Nadezhda V. Krakhmal |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 17 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |