YAP1 inhibition protects retinal vascular endothelial cells under high glucose by inhibiting autophagy
Yu-Shan Li, Wen-Qiang Liu, Hong-Dan Yu, Zhong-Fu Zuo, Xue-Zheng Liu · 2025
Read YAP1 inhibition protects retinal vascular endothelial cells under high glucose by inhibiting autophagy by Yu-Shan Li, Wen-Qiang Liu, Hong-Dan Yu, Zhong-Fu Zuo, Xue-Zheng Liu (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12728944.txt.
Description
Yu-Shan Li and co-authors present a 2025 journal article on a signaling protein that worsens diabetic eye damage. In diabetic retinopathy, high sugar injures the retina's vessel lining. The protein YAP1 rose steadily with glucose dose in two kinds of retinal vessel cells. The team then blocked it and watched what changed.
Blocking YAP1 protected the cells: fewer died, though growth slowed, and their migration and tube-building weakened. The self-eating process of autophagy eased, and a key inflammation switch stayed out of the nucleus. In diabetic mice, YAP1 knockdown helped the retina. The authors name YAP1 a candidate drug target for the disease.
Catalog record
| CREATOR | Yu-Shan Li, Wen-Qiang Liu, Hong-Dan Yu, Zhong-Fu Zuo, Xue-Zheng Liu |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 32 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |