Prostate cancer cells converge to an inflammatory-like state upon metastatic dissemination
Tina Keshavarzian, Kira Furlano, Giacomo Grillo, Lisanne Mout, Christopher Arlidge, Faizan Hasan, Ankita Nand, Migle Mikutenaite, Evdoxia Karadoulama, Ashish Goyal, Elisabeth L Pezzuto, Jessica Heilmann, Jakub Sykora, Sarah Minner, Thorsten Schlomm, Guido Sauter, Ronald Simon, Housheng Hansen He, Jo · 2025
Read Prostate cancer cells converge to an inflammatory-like state upon metastatic dissemination by Tina Keshavarzian, Kira Furlano, Giacomo Grillo, Lisanne Mout, Christopher Arlidge, Faizan Hasan, Ankita Nand, Migle Mikutenaite, Evdoxia Karadoulama, Ashish Goyal, Elisabeth L Pezzuto, Jessica Heilmann, Jakub Sykora, Sarah Minner, Thorsten Schlomm, Guido Sauter, Ronald Simon, Housheng Hansen He, Jo (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12728229.txt.
Description
Tina Keshavarzian and co-authors profiled prostate cancer spread cell by cell in two thousand twenty-five. Tumors vary widely, which hinders treatment choice. The team sampled primary tumors and matched lymph node spread. About three hundred thousand cells were profiled. Both gene activity and chromatin openness were read. Cells came from several sites per patient.
Differences between patients sat mainly in malignant cells. Within one site, malignant cells still varied in state. That variety existed despite shared clonal ancestry. Cells that spread converged on an inflammatory-like state. The shared state may be a key to metastasis. It could also offer a common drug target. Maps like this guide biopsy interpretation.
Catalog record
| CREATOR | Tina Keshavarzian, Kira Furlano, Giacomo Grillo, Lisanne Mout, Christopher Arlidge, Faizan Hasan, Ankita Nand, Migle Mikutenaite, Evdoxia Karadoulama, Ashish Goyal, Elisabeth L Pezzuto, Jessica Heilmann, Jakub Sykora, Sarah Minner, Thorsten Schlomm, Guido Sauter, Ronald Simon, Housheng Hansen He, Jo |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 70 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |