Microbiotoxicity: an under-recognised player in drug efficacy, toxicity, and health outcomes
Shirley Do Nascimento, Anastasia A Theodosiou, Chrysi Sergaki · 2025
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Description
Shirley Do Nascimento, Anastasia Theodosiou, and Chrysi Sergaki name a hidden harm in modern prescribing, in a 2025 review: the gut microbiome. Drugs well beyond antibiotics can disturb it, and so upset how it tunes immunity, inflammation, and metabolism. The authors call this harm microbiotoxicity. They trace its reach to treatment failure, to worse gains from cancer immunotherapy and vaccines, and to drug resistance that grows faster.
Once the view widens, much of the blame falls on drugs outside that class, from painkillers to psychiatric staples. The review urges prescribers and drug developers to count this harm in their ledgers. Studying how drugs and the gut microbiome affect each other, they argue, is stewardship by another name. It can guide drug choices and new drug work, lift health results, and cut harm to patients.
Catalog record
| CREATOR | Shirley Do Nascimento, Anastasia A Theodosiou, Chrysi Sergaki |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 22 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |