Histone acetylation homeodynamics navigates cell survival and apoptosis
Kang Li, Ling Tian, Wenxin Cao, Jiahui Zhang, Wenhao Zhang, Tong Lin, Shumin Huang, Yongyu Qiu, Zifeng Ruan, Jianhao Deng, Shihui Long, Subba R. Palli, Sheng Li · 2025
Read Histone acetylation homeodynamics navigates cell survival and apoptosis by Kang Li, Ling Tian, Wenxin Cao, Jiahui Zhang, Wenhao Zhang, Tong Lin, Shumin Huang, Yongyu Qiu, Zifeng Ruan, Jianhao Deng, Shihui Long, Subba R. Palli, Sheng Li (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12728225.txt.
Description
Kang Li and co-authors show how chemical marks on histones steer the choice between cell life and death in 2025. Cell death is held in check by blocker proteins and pushed by killer proteins. The gene balance between them was not fully known. Work in fruit flies maps a dynamic mark pattern on the genes for both sides.
Enzyme pairs add and remove the marks in a tuned loop. That loop sets when a hormone can trigger planned death in development. The same loop keeps blocker genes active to guard daily cell life. The mechanism is partly shared with mammals. Breaking the loop slowed tumor growth in flies and mice. The authors point to mark based drug targets.
Catalog record
| CREATOR | Kang Li, Ling Tian, Wenxin Cao, Jiahui Zhang, Wenhao Zhang, Tong Lin, Shumin Huang, Yongyu Qiu, Zifeng Ruan, Jianhao Deng, Shihui Long, Subba R. Palli, Sheng Li |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 96 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |