High-throughput triazole-based combinatorial click chemistry for the synthesis and identification of functional metal complexes
David R Husbands, Çağrı Özsan, Athi Welsh, Richard J Gammons, Angelo Frei · 2025
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Description
David Husbands and co-authors mass-produce metal compounds with click chemistry to hunt for new drugs, in work from 2025. Click steps snap simple parts into ring-shaped linkers with ease. The team built a library of near two hundred such linkers and clipped them onto five metal frames, which yielded over six hundred compounds in one sweep.
A straight-to-biology screen flagged six metal antibiotics that kill a major germ class at tiny doses with sound safety margins. Two iridium compounds also shone as catalysts in a hydrogen swap test. The authors frame the method as a fast map of metal compound space.
Catalog record
| CREATOR | David R Husbands, Çağrı Özsan, Athi Welsh, Richard J Gammons, Angelo Frei |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 83 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |