Vitamin D3 attenuates hepatic inflammation in primary biliary cholangitis by inhibiting TLR4/NF-κB mediated M1 macrophage polarization
Zhan Wang, Weize Gao, Xuedi Cheng, Nana Zhang, Wenlong Lu, Yongxin Li, Mingjun Liu · 2025
Read Vitamin D3 attenuates hepatic inflammation in primary biliary cholangitis by inhibiting TLR4/NF-κB mediated M1 macrophage polarization by Zhan Wang, Weize Gao, Xuedi Cheng, Nana Zhang, Wenlong Lu, Yongxin Li, Mingjun Liu (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12728185.txt.
Description
Zhan Wang and six co-authors test whether vitamin D3 can calm the liver inflammation of primary biliary cholangitis, an autoimmune disease. Immune cells called macrophages drive much of the damage, especially in their inflammatory M1 state. The team combined gene data analysis, patient checks, a mouse model, and cell experiments. They tracked a signaling chain, TLR4 and NF-κB, known to push macrophages toward the M1 state.
Patients' livers held extra M1 macrophages, and treatment raised vitamin levels while easing injury and shrinking that population. In mice, vitamin D3 cut inflammatory cell entry and lowered three inflammatory signals. Lab work showed it switching off the TLR4 chain, including its partner protein and two activation steps. The authors propose vitamin D3 as a supportive therapy candidate for this disease. Larger clinical tests would be needed to confirm benefit.
Catalog record
| CREATOR | Zhan Wang, Weize Gao, Xuedi Cheng, Nana Zhang, Wenlong Lu, Yongxin Li, Mingjun Liu |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 52 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |