NSUN2 mediated-aberrant 5-methylcytosine methylation regulates autophagy-related ferroptosis in oral squamous cell carcinoma progression
Yunyang Lu, Runze Li, Weidong Du, Jie Wu, Yi He, Lingyu Yuan, Xun Chen, Shiyu Lv, Fangyang Shi, Jiajun Hu, Wei Zhao, Dongsheng Yu · 2025
Read NSUN2 mediated-aberrant 5-methylcytosine methylation regulates autophagy-related ferroptosis in oral squamous cell carcinoma progression by Yunyang Lu, Runze Li, Weidong Du, Jie Wu, Yi He, Lingyu Yuan, Xun Chen, Shiyu Lv, Fangyang Shi, Jiajun Hu, Wei Zhao, Dongsheng Yu (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12728175.txt.
Description
Lu and co-authors published this cancer study in twenty twenty-five on mouth cancer. The work centers on NSUN2, a protein that tags RNA with a chemical mark. Tumors of the mouth lining often spread early and respond poorly to treatment. NSUN2 levels are high in these tumors, and high levels track with worse outcomes for patients.
The team found that NSUN2 helps tumor cells resist ferroptosis, a form of cell death driven by iron. It does so by marking a partner RNA that steadies a protein which holds back self-eating in cells. Lowering NSUN2 made cells sensitive to this death pathway again and shrank tumors in mice. Blocking NSUN2, the authors suggest, could open a new treatment angle.
Catalog record
| CREATOR | Yunyang Lu, Runze Li, Weidong Du, Jie Wu, Yi He, Lingyu Yuan, Xun Chen, Shiyu Lv, Fangyang Shi, Jiajun Hu, Wei Zhao, Dongsheng Yu |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 53 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |